Article
Rapid evolution of virus sequences in intrinsically disordered protein regions.
PLoS pathogens - 1 Dec 2014
Gitlin Leonid, Hagai Tzachi, LaBarbera Anthony, Solovey Mark, Andino Raul
Abstract excerpt
Nodamura Virus (NoV) is a nodavirus originally isolated from insects that can replicate in a wide variety of hosts, including mammals. Because of their simplicity and ability to replicate in many diverse hosts, NoV, and the Nodaviridae in general, provide a unique window into the evolution of viruses and host-virus interactions. Here we show that the C-terminus of the viral polymerase exhibits extreme structural...
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