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Discovery of mutated subnetworks associated with clinical data in cancer.

Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing - 1 Jan 2012

Vandin Fabio, Clay Patrick, Upfal Eli, Raphael Benjamin J

Abstract excerpt

A major goal of cancer sequencing projects is to identify genetic alterations that determine clinical phenotypes, such as survival time or drug response. Somatic mutations in cancer are typically very diverse, and are found in different sets of genes in different patients. This mutational heterogeneity complicates the discovery of associations between individual mutations and a clinical phenotype. This mutational...

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PMID: 22174262

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