The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations.

doi:10.1182/blood-2014-05-576157

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Article

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations.

Blood - 22 Jan 2015

Bodini Margherita, Ronchini Chiara, Giacò Luciano, Russo Anna, Melloni Giorgio E M, Luzi Lucilla, Sardella Domenico, Volorio Sara, Hasan Syed K, Ottone Tiziana, Lavorgna Serena, Lo-Coco Francesco, Candoni Anna, Fanin Renato, Toffoletti Eleonora, Iacobucci Ilaria, Martinelli Giovanni, Cignetti Alessandro, Tarella Corrado, Bernard Loris, Pelicci Pier Giuseppe, Riva Laura

Abstract excerpt

The analyses carried out using 2 different bioinformatics pipelines (SomaticSniper and MuTect) on the same set of genomic data from 133 acute myeloid leukemia (AML) patients, sequenced inside the Cancer Genome Atlas project, gave discrepant results. We subsequently tested these 2 variant-calling pipelines on 20 leukemia samples from our series (19 primary AMLs and 1 secondary AML). By validating many of the...

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PMID: 25499761
DOI: 10.1182/blood-2014-05-576157
PMCID: PMC4304104

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