Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transaldolase haploinsufficiency in subjects with acetaminophen‐induced liver failure

26 Nov 2019

Abstract excerpt

Transaldolase (TAL) is an enzyme in the pentose phosphate pathway (PPP) that generates NADPH for protection against oxidative stress. While deficiency of other PPP enzymes, such as transketolase (TKT), are incompatible with mammalian cell survival, mice lacking TAL are viable and develop progressive liver disease attributed to oxidative stress. Mice with homozygous or heterozygous TAL deficiency are predisposed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Enzymes and Metabolism
Share to Biomedical Research and Pathophysiology
Share to Metabolism and Genetic Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31769880
DOI: 10.1002/jimd.12197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transaldolase haploinsufficiency in subjects with acetaminophen‐induced liver failurePMID 31769880Read ↗

Liver Disease and Risk of Hepatocellular Carcinoma in Children With Mutations in TALDO1.Semantic proximity Read ↗

The Genomics of Elevated ALT and Adducts in Therapeutic Acetaminophen Treatment: a Pilot Study.Semantic proximity Read ↗

Hypergonadotrophic hypogonadism in a patient with transaldolase deficiency: novel mutation in the pentose phosphate pathway.Semantic proximity Read ↗

A Rare Cause of Genetic Liver Disease in Children: Transaldolase Deficiency with a Novel Pathogenic Variant in Two Siblings.Semantic proximity Read ↗

The Human Glyoxalase Gene Family in Health and DiseaseSemantic proximity Read ↗

Transaldolase deficiency: report of 12 new cases and further delineation of the phenotype.Semantic proximity Read ↗

Transaldolase deficiency caused by the homozygous p.R192C mutation of the TALDO1 gene in four Emirati patients with considerable phenotypic variability.Semantic proximity Read ↗

Characterising a healthy adult with a rare HAO1 knockout to support a therapeutic strategy for primary hyperoxaluriaSemantic proximity Read ↗

<i>In vivo</i> dissection of the mouse tyrosine catabolic pathway with CRISPR-Cas9 identifies modifier genes affecting hereditary tyrosinemia type 1Semantic proximity Read ↗

Hereditary tyrosinemia type Ⅰ: newborn screening, diagnosis and treatment.Semantic proximity Read ↗

A framework for application of metabolic modeling in yeast to predict the effects of nsSNV in human orthologs.Semantic proximity Read ↗

DHTKD1 mutations cause 2-aminoadipic and 2-oxoadipic aciduria.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.