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Article

p16(INK4a) expression in retinoblastoma: a marker of differentiation grade.

Diagnostic pathology - 11 Dec 2014

Liu Yue, Zhong Xiufeng, Wan Shangtao, Zhang Wenxin, Lin Jianxian, Zhang Ping, Li Yongping

Abstract excerpt

BACKGROUND: The tumor suppressor protein p16(INK4a) has been extensively studied in many tumors with very different results, ranging from its loss to its clear overexpression, which may be associated with degree of tumor differentiation and prognosis. However, its expression remains unclear in human retinoblastoma (RB), a common malignant tumor of retina in childhood. The aim of this study was to explore the...

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Identifiers

PMID: 25499675
DOI: 10.1186/s13000-014-0180-1
PMCID: PMC4300043

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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