Article
Prevalence of high-risk human papillomavirus genotypes in retinoblastoma.
The British journal of ophthalmology - 1 Jul 2011
Anand Bhuvaneswari, Ramesh C, Appaji L, Kumari B S Aruna, Shenoy A M, Nanjundappa, Jayshree R S, Kumar Rekha V
Abstract excerpt
BACKGROUND: The human papillomavirus (HPV) is an important aetiological agent in cancer but its involvement in retinoblastomas (RBs) is controversial. METHODS: 64 formalin-fixed paraffin-embedded tissue blocks and 19 fresh-frozen specimens were subjected to multiplex PCR using PGMY09/11 primers, HPV genotyping, non-isotopic in situ hybridisation and immunohistochemistry for pRb and p16(INK4a). RESULTS: 24% of RBs...
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