Article
Warfarin Dosing in Patients With CYP2C9*5 Variant Alleles.
Clinical pharmacology and therapeutics - 1 Apr 2022
Lindley Kathryn J, Limdi Nita A, Cavallari Larisa H, Perera Minoli A, Lenzini Petra, Johnson Julie A, Wu Alan H B, Ridker Paul M, King Cristi R, Eby Charles S, Patel Shitalben, Shah Shimoli V, Beasley T Mark, Li Juan, Gage Brian F
Abstract excerpt
Pharmacogenetic dosing improves the accuracy of warfarin dosing, but current pharmacogenetic dosing algorithms are less accurate in populations of African ancestry. The cytochrome P450 2C9*5 (CYP2C9*5) allele is found almost exclusively in populations of African ancestry, and in vitro studies suggest CYP2C9*5 is associated with reduced clearance of warfarin. The clinical relevance of this single-nucleotide...
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