Article
Models of α-synuclein aggregation in Parkinson's disease.
Acta neuropathologica communications - 13 Dec 2014
Giráldez-Pérez Rosa, Antolín-Vallespín Mónica, Muñoz María, Sánchez-Capelo Amelia
Abstract excerpt
Parkinson's disease (PD) is not only characterized by motor disturbances but also, by cognitive, sensory, psychiatric and autonomic dysfunction. It has been proposed that some of these symptoms might be related to the widespread pathology of α-synuclein (α-syn) aggregation in different nuclei of the central and peripheral nervous system. However, the pathogenic formation of α-syn aggregates in different brain...
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