Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β Cells

1 Dec 2014

Abstract excerpt

Development and function of pancreatic β cells involve the regulated activity of specific transcription factors. RFX6 is a transcription factor essential for mouse β cell differentiation that is mutated in monogenic forms of neonatal diabetes. However, the expression and functional roles of RFX6 in human β cells, especially in pathophysiological conditions, are poorly explored. We demonstrate the presence of RFX6...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Management and Research
Share to Metabolism, Diabetes, and Cancer
Share to Pancreatic function and diabetes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 25497100
DOI: 10.1016/j.celrep.2014.11.010

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RFX6 Regulates Insulin Secretion by Modulating Ca2+ Homeostasis in Human β CellsPMID 25497100Read ↗

Rfx6 Maintains the Functional Identity of Adult Pancreatic β CellsSemantic proximity Read ↗

RFX6 Maintains Gene Expression and Function of Adult Human Islet α-CellsSemantic proximity Read ↗

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function.Semantic proximity Read ↗

<i>RFX6</i> haploinsufficiency predisposes to diabetes through impaired beta cell functionalitySemantic proximity Read ↗

The dual role of RFX6 in directing β cell development and insulin production.Semantic proximity Read ↗

Mitchell-Riley Syndrome: Improving Clinical Outcomes and Searching for Functional Impact of RFX-6 Mutations.Semantic proximity Read ↗

Deletion of RFX6 impairs iPSC-derived islet organoid development and survival, with no impact on PDX1+/NKX6.1+ progenitorsSemantic proximity Read ↗

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.Semantic proximity Read ↗

RFX6-mediated dysregulation defines human β cell dysfunction in early type 2 diabetesSemantic proximity Read ↗

RFX6 is needed for the development and maintenance of the β-cell phenotype.Semantic proximity Read ↗

GATA6 Controls Insulin Biosynthesis and Secretion in Adult β-Cells.Semantic proximity Read ↗

The Transcription Factor Rfx3 Regulates β-Cell Differentiation, Function, and Glucokinase ExpressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.