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Article

Functional analysis of Rfx6 and mutant variants associated with neonatal diabetes.

Developmental biology - 1 Mar 2011

Pearl Esther J, Jarikji Zeina, Horb Marko E

Abstract excerpt

Mutations in rfx6 were recently associated with Mitchell-Riley syndrome, which involves neonatal diabetes, and other digestive system defects. To better define the function of Rfx6 in early endoderm development we cloned the Xenopus homologue. Expression of rfx6 begins early, showing broad expression throughout the anterior endoderm; at later stages rfx6 expression becomes restricted to the endocrine cells of the...

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Identifiers

PMID: 21215266
DOI: 10.1016/j.ydbio.2010.12.043
PMCID: PMC3042741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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