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Article

Optimization of rotamers prior to template minimization improves stability predictions made by computational protein design.

Protein science : a publication of the Protein Society - 1 Apr 2015

Davey James A, Chica Roberto A

Abstract excerpt

Computational protein design (CPD) predictions are highly dependent on the structure of the input template used. However, it is unclear how small differences in template geometry translate to large differences in stability prediction accuracy. Herein, we explored how structural changes to the input template affect the outcome of stability predictions by CPD. To do this, we prepared alternate templates by Rotamer...

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Identifiers

PMID: 25492709
DOI: 10.1002/pro.2618
PMCID: PMC4380985

Genes

CPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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