Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants 2(P24T) or 3(L48V) in Norwegian patients.

Seizure - 1 Feb 2017

Shirzadi Maryam, Reimers Arne, Helde Grethe, Sjursen Wenche, Brodtkorb Eylert

Abstract excerpt

PURPOSE: High initial serum concentrations increase the risk of cutaneous adverse reactions. Genetic variants of the main metabolizing isoenzyme, uridine diphosphate glucuronosyltransferase (UGT) 1A4 influence the elimination of lamotrigine (LTG). Our aim was to investigate the potential association between the two best studied variants, *2 (P24T) and *3 (L48V), and the occurrence non-bullous skin reactions from...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Epilepsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucuronosyltransferase

Share to Lamotrigine

Share to Norway

Share to Pharmacogenetics

Share to Skin Diseases

Share to Triazines

Source

Identifiers

PMID: 28068583
DOI: 10.1016/j.seizure.2016.12.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between non-bullous skin reactions from lamotrigine and heterozygosity of UGT1A4 genetic variants *2(P24T) or *3(L48V) in Norwegian patients.PMID 28068583Read ↗

Frequencies of UGT1A4*2 (P24T) and *3 (L48V) and their effects on serum concentrations of lamotrigine.Semantic proximity Read ↗

Meta-analysis of the Influence of UGT Genetic Polymorphisms on Lamotrigine Concentration.Semantic proximity Read ↗

Effect of UGT1A4, UGT2B7, UGT2B15, UGT2B17 and ABC1B polymorphisms on lamotrigine metabolism in Danish patients.Semantic proximity Read ↗

Clinically Relevant Effect of UGT1A4*3 on Lamotrigine Serum Concentration Is Restricted to Postmenopausal Women-A Study Matching Therapeutic Drug Monitoring and Genotype Data From 534 Patients.Semantic proximity Read ↗

Functional analysis of UGT1A4(P24T) and UGT1A4(L48V) variant enzymes.Semantic proximity Read ↗

UGT polymorphisms and lamotrigine clearance during pregnancy.Semantic proximity Read ↗

Influence of the UGT2B7 -161C>T polymorphism on the population pharmacokinetics of lamotrigine in Thai patients.Semantic proximity Read ↗

Association between HLA-DRB1*0405, -DQB1*0401 and -DQA1*0303 alleles and lamotrigine-induced cutaneous adverse drug reactions. A pilot case-control study from Japan.Semantic proximity Read ↗

Rash and multiorgan dysfunction following lamotrigine: could genetic be involved?Semantic proximity Read ↗

UGT1A4*3 polymorphism influences serum concentration and therapeutic effect of lamotrigine for epilepsy treatment: A meta-analysis.Semantic proximity Read ↗

UGT2B7_-161C>T polymorphism is associated with lamotrigine concentration-to-dose ratio in a multivariate study.Semantic proximity Read ↗

Effects of Comedication and Genetic Factors on the Population Pharmacokinetics of Lamotrigine: A Prospective Analysis in Chinese Patients With EpilepsySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.