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Article

It is not all about BRCA: Cullin-Ring ubiquitin Ligases in ovarian cancer.

British journal of cancer - 6 Jan 2015

Carlucci A, D'Angiolella V

Abstract excerpt

Mutations in the BRCA1 and BRCA2 genes predispose individuals to the development of breast and ovarian cancers. As a result, biochemical functions of BRCA1 and BRCA2 proteins are being characterised in great detail. These studies have prompted the use of PARP inhibitors to treat BRCA1 and BRCA2-deficient ovarian cancers. This example of synthetic lethality represents a conceptual progress made recently in the...

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Identifiers

PMID: 25490527
DOI: 10.1038/bjc.2014.594
PMCID: PMC4453745

Genes

BRCA1
BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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