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Article

A COP1-GATA2 axis suppresses AR signaling and prostate cancer

17 Oct 2022

Abstract excerpt

Androgen receptor (AR) signaling is crucial for driving prostate cancer (PCa), the most diagnosed and the second leading cause of death in male patients with cancer in the United States. Androgen deprivation therapy is initially effective in most instances of AR-positive advanced or metastatic PCa. However, patients inevitably develop lethal castration-resistant PCa (CRPC), which is also resistant to the...

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PMID: 36251994
DOI: 10.1073/pnas.2205350119

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