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Article

The androgen receptor interacts with GATA3 to transcriptionally regulate a luminal epithelial cell phenotype in breast cancer.

Genome biology - 5 Feb 2024

Hosseinzadeh Leila, Kikhtyak Zoya, Laven-Law Geraldine, Pederson Stephen M, Puiu Caroline G, D'Santos Clive S, Lim Elgene, Carroll Jason S, Tilley Wayne D, Dwyer Amy R, Hickey Theresa E

Abstract excerpt

BACKGROUND: The androgen receptor (AR) is a tumor suppressor in estrogen receptor (ER) positive breast cancer, a role sustained in some ER negative breast cancers. Key factors dictating AR genomic activity in a breast context are largely unknown. Herein, we employ an unbiased chromatin immunoprecipitation-based proteomic technique to identify endogenous AR interacting co-regulatory proteins in ER positive and...

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Share to Breast Neoplasms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GATA3 Transcription Factor

Share to Jumonji Domain-Containing Histone Demethylases

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Share to Receptors, Androgen

Source

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Identifiers

PMID: 38317241
DOI: 10.1186/s13059-023-03161-y
PMCID: PMC10840202

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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