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Article

CtBP2 modulates the androgen receptor to promote prostate cancer progression.

Cancer research - 15 Nov 2014

Takayama Ken-Ichi, Suzuki Takashi, Fujimura Tetsuya, Urano Tomohiko, Takahashi Satoru, Homma Yukio, Inoue Satoshi

Abstract excerpt

The androgen receptor (AR) is the key driver of both early and advanced prostate cancer, making a complete understanding of its regulation important. Here, we report the identification of multiple AR-binding sites in the gene encoding the transcription factor CtBP2 (carboxyl terminal-binding protein), genetic variations of which have been associated with prostate cancer susceptibility. Notably, we found that SNPs...

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PMID: 25228652
DOI: 10.1158/0008-5472.CAN-14-1030

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CTBP2

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