Article
Multidimensional Characterization of Tumor-Immune Architecture Reveals Clinically Relevant Classic Hodgkin Lymphoma Subtypes.
Cancer discovery - 1 May 2026
Aoki Tomohiro, Duns Gerben, Rai Shinya, Jiang Aixiang, Lytle Andrew, Yin Yifan, Kishida Makoto, Yu Li Michael, Lee Cecilia, Smorra Denise, Hilton Laura K, Healy Shannon, Alig Stefan K, Shahrokh Esfahani Mohammad, Sarkozy Clementine, Hung Stacy S, Milne Katy, Telenius Adele, O'Brien Luke, Wong Jasper C H, Cassidy Claudia, Fujisawa Manabu, Strong Celia, Goodyear Talia, Di Vito Chantal, Luksik Cassandra, Edin Glenn, Gonzalez Laura, Rangel Patiño Juan, Hong Michael, Wu Shaocheng, Lee Eric, Sakhdari Ali, Takata Katsuyoshi, Miyata-Takata Tomoko, Boyle Merrill, Ben-Neriah Susana, Weng Andrew P, Xu Alexander, Merchant Akil, Roth Andrew, Crump Michael, Kuruvilla John, Prica Anca, Kridel Robert, Huntsman David G, Nelson Brad H, Farinha Pedro, Morin Ryan D, Alizadeh Ash A, Savage Kerry J, Scott David W, Steidl Christian
Abstract excerpt
The tissue architecture of classic Hodgkin lymphoma (cHL) is unique among cancers and is characterized by rare malignant Hodgkin and Reed-Sternberg cells that coevolve with a complex ecosystem of immune cells in the tumor microenvironment (TME). The lack of a comprehensive systems-level interrogation has hindered the description of disease heterogeneity and clinically relevant molecular subtypes. In this study,...
Topics
- Humans
- Hodgkin Disease
- Tumor Microenvironment
- Gene Expression Profiling
- Mutation