Article
Phosphorylation of ribosomal protein S6 kinase 1 at Thr421/Ser424 and dephosphorylation at Thr389 regulates SP600125-induced polyploidization of megakaryocytic cell lines.
PloS one - 1 Jan 2014
Li Chang-Ling, Yang Jin-Gang, Lin Di, Zhao Yong-Shan, Liu Shuo, Xing Si-Ning, Zhao Song, Chen Cong-Qin, Jiang Zhi-Ming, Pu Fei-Fei, Cao Jian-Ping, Ma Dong-Chu
Abstract excerpt
Megakaryocytes (MKs) are one of the few cell types that become polyploid; however, the mechanisms by which these cells are designated to become polyploid are not fully understood. In this investigation, we successfully established two relatively synchronous polyploid cell models by inducing Dami and CMK cells with SP600125. We found that SP600125 induced the polyploidization of Dami and CMK cells, concomitant...
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