Article
A Fox2-dependent fatty acid ß-oxidation pathway coexists both in peroxisomes and mitochondria of the ascomycete yeast Candida lusitaniae.
PloS one - 1 Jan 2014
Gabriel Frédéric, Accoceberry Isabelle, Bessoule Jean-Jacques, Salin Bénédicte, Lucas-Guérin Marine, Manon Stephen, Dementhon Karine, Noël Thierry
Abstract excerpt
It is generally admitted that the ascomycete yeasts of the subphylum Saccharomycotina possess a single fatty acid ß-oxidation pathway located exclusively in peroxisomes, and that they lost mitochondrial ß-oxidation early during evolution. In this work, we showed that mutants of the opportunistic pathogenic yeast Candida lusitaniae which lack the multifunctional enzyme Fox2p, a key enzyme of the ß-oxidation...
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