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Article

Contributions of the peroxisome and β-oxidation cycle to biotin synthesis in fungi.

The Journal of biological chemistry - 9 Dec 2011

Magliano Pasqualina, Flipphi Michel, Arpat Bulak A, Delessert Syndie, Poirier Yves

Abstract excerpt

The first step in the synthesis of the bicyclic rings of D-biotin is mediated by 8-amino-7-oxononanoate (AON) synthase, which catalyzes the decarboxylative condensation of l-alanine and pimelate thioester. We found that the Aspergillus nidulans AON synthase, encoded by the bioF gene, is a peroxisomal enzyme with a type 1 peroxisomal targeting sequence (PTS1). Localization of AON to the peroxisome was essential...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21998305
DOI: 10.1074/jbc.M111.279687
PMCID: PMC3234907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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