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Article

p53-Dependent DNA damage response sensitive to editing-defective tRNA synthetase in zebrafish.

Proceedings of the National Academy of Sciences of the United States of America - 26 Jul 2016

Song Youngzee, Shi Yi, Carland Tristan M, Lian Shanshan, Sasaki Tomoyuki, Schork Nicholas J, Head Steven R, Kishi Shuji, Schimmel Paul

Abstract excerpt

Brain and heart pathologies are caused by editing defects of transfer RNA (tRNA) synthetases, which preserve genetic code fidelity by removing incorrect amino acids misattached to tRNAs. To extend understanding of the broader impact of synthetase editing reactions on organismal homeostasis, and based on effects in bacteria ostensibly from small amounts of mistranslation of components of the replication apparatus,...

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Share to Amino Acyl-tRNA Synthetases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Embryo, Nonmammalian

Share to Gene Expression Regulation, Developmental

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Share to Tumor Suppressor Protein p53

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Source

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Identifiers

PMID: 27402763
DOI: 10.1073/pnas.1608139113
PMCID: PMC4968768

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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