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Article

The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative neoplasms.

Annals of hematology - 1 May 2015

Soler G, Bernal-Vicente A, Antón A I, Torregrosa J M, Caparrós-Pérez E, Sánchez-Serrano I, Martínez-Pérez A, Sánchez-Vega B, Vicente V, Ferrer-Marin F

Abstract excerpt

Somatic mutations in the CALR gene were recently discovered in a substantial proportion of Philadelphia-negative chronic myeloproliferative neoplasm (cMPN) patients lacking JAK2 and MPL mutations. Somatically acquired defects are not the only pathogenic mechanism involved in these disorders. Since germline JAK2 46/1 haplotype predisposes to cMPN-associated mutations, including JAK2V617F and MPLW515K7L, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25482455
DOI: 10.1007/s00277-014-2266-y

Genes

CALR
JAK2
MPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative neoplasms.PMID 25482455Read ↗

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