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Article

JAK2 GGCC haplotype in MPL mutated myeloproliferative neoplasms.

American journal of hematology - 1 Jul 2012

Pietra Daniela, Casetti Ilaria, Da Vià Matteo C, Elena Chiara, Milanesi Chiara, Rumi Elisa

Abstract excerpt

JAK2 (V617F) is associated with a genetic predisposition to its acquisition,as it is preferentially found in subjects with a common constitutional JAK2 haplotype known as 46/1 or GGCC. A recent study suggests that a genetic predisposition to acquisition of MPL mutation may exist in sporadic patie...

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Source

Identifiers

PMID: 22565617
DOI: 10.1002/ajh.23229

Genes

JAK2
MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22565617-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

JAK2 GGCC haplotype in MPL mutated myeloproliferative neoplasms.PMID 22565617Read ↗

The JAK2 GGCC (46/1) Haplotype in Myeloproliferative Neoplasms: Causal or Random?Semantic proximity Read ↗

The JAK2 46/1 haplotype predisposes to MPL-mutated myeloproliferative neoplasms.Semantic proximity Read ↗

JAK2 46/1 (GGCC) Haplotype: A Biomarker for Oncogenesis, Risk Stratification, and Drug Resistance in Myeloproliferative NeoplasmsSemantic proximity Read ↗

Association of JAK2 Haplotype GGCC_46/1 with the Response to Onco-Drug in MPNs Patients Positive for JAK2V617F MutationSemantic proximity Read ↗

The G allele of the JAK2 rs10974944 SNP, part of JAK2 46/1 haplotype, is strongly associated with JAK2 V617F-positive myeloproliferative neoplasms.Semantic proximity Read ↗

The Contribution of JAK2 46/1 Haplotype in the Predisposition to Myeloproliferative Neoplasms.Semantic proximity Read ↗

The JAK2 46/1 haplotype does not predispose to CALR-mutated myeloproliferative neoplasms.Semantic proximity Read ↗

JAK2 haplotype is a major risk factor for the development of myeloproliferative neoplasms.Semantic proximity Read ↗

JAK2 46/1 haplotype is associated with JAK2 V617F--positive myeloproliferative neoplasms in Brazilian patients.Semantic proximity Read ↗

JAK2 germline genetic variation affects disease susceptibility in primary myelofibrosis regardless of V617F mutational status: nullizygosity for the JAK2 46/1 haplotype is associated with inferior survival.Semantic proximity Read ↗

JAK2 46/1 haplotype is associated with JAK2 V617F-positive myeloproliferative neoplasms in Japanese patients.Semantic proximity Read ↗

Evaluation of the association between the JAK2 46/1 haplotype and chronic myeloproliferative neoplasms in a Brazilian population.Semantic proximity Read ↗

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