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Genes, epigenetic regulation and environmental factors: which is the most relevant in developing autoimmune diseases?

Autoimmunity reviews - 1 Jun 2012

Costenbader Karen H, Gay Steffen, Alarcón-Riquelme Marta E, Iaccarino Luca, Doria Andrea

Abstract excerpt

Autoimmune diseases such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis and inflammatory bowel disease, have complex pathogeneses and likely multifactorial etiologies. The current paradigm for understanding their development is that the disease is triggered in genetically-susceptible individuals by exposure to environmental factors. Some of these environmental factors have been...

Topics

Animals
Autoimmune Diseases
Epigenesis, Genetic
Gene-Environment Interaction
Genetic Predisposition to Disease
Herpesviridae
Humans
Metagenomics
Pathology, Molecular
Risk Factors

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PMID: 22041580
DOI: 10.1016/j.autrev.2011.10.022

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