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Article

Microevolution of Candida albicans in macrophages restores filamentation in a nonfilamentous mutant.

PLoS genetics - 1 Dec 2014

Wartenberg Anja, Linde Jörg, Martin Ronny, Schreiner Maria, Horn Fabian, Jacobsen Ilse D, Jenull Sabrina, Wolf Thomas, Kuchler Karl, Guthke Reinhard, Kurzai Oliver, Forche Anja, d'Enfert Christophe, Brunke Sascha, Hube Bernhard

Abstract excerpt

Following antifungal treatment, Candida albicans, and other human pathogenic fungi can undergo microevolution, which leads to the emergence of drug resistance. However, the capacity for microevolutionary adaptation of fungi goes beyond the development of resistance against antifungals. Here we used an experimental microevolution approach to show that one of the central pathogenicity mechanisms of C. albicans, the...

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Identifiers

PMID: 25474009
DOI: 10.1371/journal.pgen.1004824
PMCID: PMC4256171

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Source receipt: pubmed, retrieved 7 Sept 2026.

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