Global gene deletion analysis exploring yeast filamentous growth.

doi:10.1126/science.1224339

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Article

Global gene deletion analysis exploring yeast filamentous growth.

Science (New York, N.Y.) - 14 Sept 2012

Ryan Owen, Shapiro Rebecca S, Kurat Christoph F, Mayhew David, Baryshnikova Anastasia, Chin Brian, Lin Zhen-Yuan, Cox Michael J, Vizeacoumar Frederick, Cheung Doris, Bahr Sondra, Tsui Kyle, Tebbji Faiza, Sellam Adnane, Istel Fabian, Schwarzmüller Tobias, Reynolds Todd B, Kuchler Karl, Gifford David K, Whiteway Malcolm, Giaever Guri, Nislow Corey, Costanzo Michael, Gingras Anne-Claude, Mitra Robi David, Andrews Brenda, Fink Gerald R, Cowen Leah E, Boone Charles

Abstract excerpt

The dimorphic switch from a single-cell budding yeast to a filamentous form enables Saccharomyces cerevisiae to forage for nutrients and the opportunistic pathogen Candida albicans to invade human tissues and evade the immune system. We constructed a genome-wide set of targeted deletion alleles and introduced them into a filamentous S. cerevisiae strain, Σ1278b. We identified genes involved in morphologically...

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PMID: 22984072
DOI: 10.1126/science.1224339

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