Article
Association between the rs7583431 single nucleotide polymorphism close to the activating transcription factor 2 gene and the analgesic effect of fentanyl in the cold pain test.
Neuropsychopharmacology reports - 1 Jun 2018
Aoki Yoshinori, Nishizawa Daisuke, Yoshida Kaori, Hasegawa Junko, Kasai Shinya, Takahashi Kaori, Koukita Yoshihiko, Ichinohe Tatsuya, Hayashida Masakazu, Fukuda Ken-Ichi, Ikeda Kazutaka
Abstract excerpt
BACKGROUND: Activating transcription factor 2 (ATF2) is a member of the leucine zipper family of DNA binding proteins and is widely distributed in tissues. Several recent studies have demonstrated that this protein is involved in mechanisms that are related to pain and inflammation. However, unclear is whether polymorphisms of the ATF2 gene, which encodes the human ATF2 protein, influence pain or analgesic...
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