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Whole Genome Transcript Profiling of Drug Induced Steatosis in Rats Reveals a Gene Signature Predictive of Outcome

3 Dec 2014

Abstract excerpt

Drug induced steatosis (DIS) is characterised by excess triglyceride accumulation in the form of lipid droplets (LD) in liver cells. To explore mechanisms underlying DIS we interrogated the publically available microarray data from the Japanese Toxicogenomics Project (TGP) to study comprehensively whole genome gene expression changes in the liver of treated rats. For this purpose a total of 17 and 12 drugs which...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 25470483
DOI: 10.1371/journal.pone.0114085

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