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Article

Gene expression profiling in rat liver treated with compounds inducing phospholipidosis.

Toxicology and applied pharmacology - 15 Jun 2008

Hirode Mitsuhiro, Ono Atsushi, Miyagishima Toshikazu, Nagao Taku, Ohno Yasuo, Urushidani Tetsuro

Abstract excerpt

We have constructed a large-scale transcriptome database of rat liver treated with various drugs. In an effort to identify a biomarker for diagnosis of hepatic phospholipidosis, we extracted 78 probe sets of rat hepatic genes from data of 5 drugs, amiodarone, amitriptyline, clomipramine, imipramine, and ketoconazole, which actually induced this phenotype. Principal component analysis (PCA) using these probes...

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Identifiers

PMID: 18355885
DOI: 10.1016/j.taap.2008.01.036

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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