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Article

Analysis of receptor tyrosine kinase ROS1-positive tumors in non-small cell lung cancer: identification of a FIG-ROS1 fusion.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2012

Rimkunas Victoria M, Crosby Katherine E, Li Daiqiang, Hu Yerong, Kelly Meghan E, Gu Ting-Lei, Mack Jennifer S, Silver Matthew R, Zhou Xinmin, Haack Herbert

Abstract excerpt

PURPOSE: To deepen our understanding of mutant ROS1 expression, localization, and frequency in non-small cell lung cancer (NSCLC), we developed a highly specific and sensitive immunohistochemistry (IHC)-based assay that is useful for the detection of wild-type and mutant ROS1. EXPERIMENTAL DESIGN: We analyzed 556 tumors with the ROS1 D4D6 rabbit monoclonal antibody IHC assay to assess ROS1 expression levels and...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, erbB-1

Share to Membrane Transport Proteins

Share to Oncogene Proteins, Fusion

Share to Protein-Tyrosine Kinases

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Source

Identifiers

PMID: 22661537
DOI: 10.1158/1078-0432.CCR-11-3351

Genes

ROS1
ALK
EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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