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MicroRNA dysregulations in Merkel cell carcinoma: Molecular mechanisms and clinical applications

7 Dec 2022

Abstract excerpt

Merkel cell carcinoma (MCC) is an aggressive skin malignancy with two distinct etiologies. The first, which accounts for the highest proportion, is caused by Merkel cell polyomavirus (MCPyV), a DNA tumor virus. A second, UV-induced, MCC form has also been identified. Few MCC diagnostic, prognostic, and therapeutic options are available. MicroRNAs (miRNAs) are small noncoding RNA molecules, which play a key role...

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PMID: 36477874
DOI: 10.1002/jmv.28375

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