Activation of PI3K signaling in Merkel cell carcinoma.

doi:10.1158/1078-0432.CCR-11-2308

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Article

Activation of PI3K signaling in Merkel cell carcinoma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2012

Nardi Valentina, Song Youngchul, Santamaria-Barria Juan A, Cosper Arjola K, Lam Quynh, Faber Anthony C, Boland Genevieve M, Yeap Beow Y, Bergethon Kristin, Scialabba Vanessa L, Tsao Hensin, Settleman Jeffrey, Ryan David P, Borger Darrell R, Bhan Atul K, Hoang Mai P, Iafrate Anthony J, Cusack James C, Engelman Jeffrey A, Dias-Santagata Dora

Abstract excerpt

PURPOSE: Merkel cell carcinoma (MCC) is an aggressive cutaneous neuroendocrine tumor, often metastatic at presentation, for which current chemotherapeutic regimens are largely ineffective. As its pathogenesis is still unknown, we hypothesized that deregulation of signaling pathways commonly activated in cancer may contribute to MCC tumorigenesis and may provide insights into targeted therapy approaches for this...

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PMID: 22261808
DOI: 10.1158/1078-0432.CCR-11-2308
PMCID: PMC3912509

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