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Article

High tumor mutational burden and PIK3CA mutations correlate with poor Merkel cell carcinoma-specific survival.

JCI insight - 22 Apr 2026

Lobo Matheus, Bahar Furkan, Schnabel Julia L, Neto Joao P Duprat, Shetty Aniket, Khaddour Karam, Thakuria Manisha, Silk Ann W, DeCaprio James A

Abstract excerpt

Merkel cell carcinoma (MCC) is a neuroendocrine carcinoma of the skin characterized by poor prognosis. This study aimed to explore the relationship between genetic alterations, tumor mutational burden (TMB), and MCC-specific survival (MCC-SS) in patients who underwent genomic profiling of tumors with OncoPanel. Univariate and multivariable analysis were used to assess the impact of genetic alterations on MCC-SS....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Carcinoma, Merkel Cell

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Source

Open in PubMed Open full text

Identifiers

PMID: 42018651
DOI: 10.1172/jci.insight.197108
PMCID: PMC13135387

Genes

MCC
PIK3CA
KDR
RET
SETBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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