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Article

Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.

Bioorganic & medicinal chemistry letters - 15 Dec 2014

Kozakai Yuuki, Kamada Rui, Kiyota Yuhei, Yoshimura Fumihiko, Tanino Keiji, Sakaguchi Kazuyasu

Abstract excerpt

PPM1D is a p53-inducible Ser/Thr phosphatase. One of the main functions of PPM1D in normal cells is to act as a negative regulator of the p53 tumor suppressor by dephosphorylating p53 and several kinases. PPM1D is considered an oncoprotein owing to both its functions and the fact that gene amplification and overexpression of PPM1D are reported in several tumors. Recently, PPM1D mutations resulting in C-terminal...

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Identifiers

PMID: 25466181
DOI: 10.1016/j.bmcl.2014.10.093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.PMID 25466181Read ↗

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