Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activity

20 May 2002

Abstract excerpt

No abstract is available from the source.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to RNA modifications and cancer

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 12021785
DOI: 10.1038/ng894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amplification of PPM1D in human tumors abrogates p53 tumor-suppressor activityPMID 12021785Read ↗

The role of PPM1D in cancer and advances in studies of its inhibitorsSemantic proximity Read ↗

[Function of Proto-oncogene Product PPM1D and Development of PPM1D Inhibitors for Cancer Chemotherapy].Semantic proximity Read ↗

Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End.Semantic proximity Read ↗

PPM1D gene amplification and overexpression in breast cancer: a qRT-PCR and chromogenic in situ hybridization studySemantic proximity Read ↗

PPM1D in Solid and Hematologic Malignancies: Friend and Foe?Semantic proximity Read ↗

PPM1D, a Promising Therapeutic Target Uncovered Through shRNA Library Screening, Plays a Pivotal Role in Regulating the Progression of Breast CancerSemantic proximity Read ↗

PPM1D modulates hematopoietic cell fitness and response to DNA damage and is a therapeutic target in myeloid malignancy.Semantic proximity Read ↗

PPM1D suppresses p53-dependent transactivation and cell death by inhibiting the Integrated Stress ResponseSemantic proximity Read ↗

Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D.Semantic proximity Read ↗

Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice.Semantic proximity Read ↗

Induction of PPM1D following DNA-damaging treatments through a conserved p53 response element coincides with a shift in the use of transcription initiation sitesSemantic proximity Read ↗

Truncating mutations of PPM1D are found in blood DNA samples of lung cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.