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Article

Hepatitis C virus variants resistant to macrocyclic NS3-4A inhibitors subvert IFN-β induction by efficient MAVS cleavage.

Journal of hepatology - 1 Apr 2015

Welsch Christoph, Haselow Katrin, Gouttenoire Jérôme, Schneider Markus, Morikawa Kenichi, Martinez Yolanda, Susser Simone, Sarrazin Christoph, Zeuzem Stefan, Antes Iris, Moradpour Darius, Lange Christian M

Abstract excerpt

BACKGROUND & AIMS: The hepatitis C virus (HCV) NS3-4A protease is essential for the HCV life cycle and a prime target of antiviral treatment strategies. Protease inhibitors, however, are limited by emergence of resistance-associated amino acid variants (RAVs). The capacity to cleave and inactivat...

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Source

Identifiers

PMID: 25463536
DOI: 10.1016/j.jhep.2014.11.009

Genes

MAVS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25463536-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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