Article

Hepatitis C Virus Drugs Simeprevir And Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV2 Replication

2020-12-03

Abstract excerpt

Effective control of COVID-19 requires antivirals directed against SARS-CoV-2 virus. Here we assess ten available HCV protease inhibitor drugs as potential SARS-CoV-2 antivirals. There is a striking structural similarity of the substrate binding clefts of SARS-CoV-2 M<sup>pro</sup> and HCV NS3/4A proteases, and virtual docking experiments show that all ten HCV drugs can potentially bind into the M<sup>pro</sup> bi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e42e2eb7-f9c3-5512-a264-07aabd3e0f44
DOI: 10.2139/ssrn.3742249

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hepatitis C Virus Drugs Simeprevir And Grazoprevir Synergize with Remdesivir to Suppress SARS-CoV2 ReplicationDOI 10.2139/ssrn.3742249Read

Hepatitis C Virus Protease Inhibitors Show Differential Efficacy and Interactions with Remdesivir for Treatment of SARS-CoV-2 In VitroSemantic proximity Read

Simeprevir Potently Suppresses SARS-CoV‑2 Replication\nand Synergizes with RemdesivirSemantic proximity Read

Simeprevir Potently Suppresses SARS-CoV‑2 Replication and Synergizes with RemdesivirSemantic proximity Read

Computational Target-Based Drug Repurposing of Elbasvir, an Antiviral Drug Predicted to Bind Multiple SARS-CoV-2 ProteinsSemantic proximity Read

Hepatitis C RNA-dependent RNA polymerase inhibitors: a review of structure-activity and resistance relationships; different scaffolds and mutations.Semantic proximity Read

Direct-acting antiviral agents for hepatitis C: structural and mechanistic insights.Semantic proximity Read

Anti-HIV and Anti-HCV drugs are the putative inhibitors of RNA-dependent-RNA polymerase activity of NSP12 of the SARS CoV-2 (COVID-19)Semantic proximity Read

The Hepatitis C Virus Nonstructural Protein 2 (NS2): An Up-and-Coming Antiviral Drug TargetSemantic proximity Read

Development of optimized drug-like small molecule inhibitors of the SARS-CoV-2 3CL protease for treatment of COVID-19Semantic proximity Read

A Structure-Based Computational Pipeline for Broad-Spectrum Antiviral DiscoverySemantic proximity Read

SARS-CoV-2 Resistance to Small Molecule InhibitorsSemantic proximity Read

Potential Inhibitors Targeting RNA-Dependent RNA Polymerase Activity (NSP12) of SARS-CoV-2Semantic proximity Read