Article
The dynamic change of phenotypic markers of smooth muscle cells in an animal model of cerebral small vessel disease.
Microvascular research - 1 Jan 2021
Liu Na, Xue Yang, Tang Jie, Zhang Miaoyi, Ren Xue, Fu Jianhui
Abstract excerpt
BACKGROUND: The pathological character of cerebral small vessel disease (CSVD) is the dysfunction of cerebral small arteries caused by risk factors. A switch from the contractile phenotype to the synthetic phenotype of vascular smooth muscle cells (SMCs) can decrease the contractility of arteries. The alteration of the vascular wall extracellular matrix (ECM) is found to regulate the process. We speculated that...
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