Article
The HLA-G genotype is potentially associated with idiopathic recurrent spontaneous abortion.
Molecular human reproduction - 1 Apr 2001
Pfeiffer K A, Fimmers R, Engels G, van der Ven H, van der Ven K
Abstract excerpt
The causes for recurrent spontaneous abortion (RSA) remain unknown in a large proportion of the cases. Human leukocyte antigen (HLA)-G and HLA-E are expressed on invasive trophoblast cells, and are supposed to confer to materno-fetal tolerance. A total of 14 different nucleotide sequences have been described for HLA-G, including one dysfunctional null allele (HLA-G*0105N), while five different sequences have been...
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