Article
Identification of Ppk26, a DEG/ENaC Channel Functioning with Ppk1 in a Mutually Dependent Manner to Guide Locomotion Behavior in Drosophila.
Cell reports - 20 Nov 2014
Gorczyca David A, Younger Susan, Meltzer Shan, Kim Sung Eun, Cheng Li, Song Wei, Lee Hye Young, Jan Lily Yeh, Jan Yuh Nung
Abstract excerpt
A major gap in our understanding of sensation is how a single sensory neuron can differentially respond to a multitude of different stimuli (polymodality), such as propio- or nocisensation. The prevailing hypothesis is that different stimuli are transduced through ion channels with diverse properties and subunit composition. In a screen for ion channel genes expressed in polymodal nociceptive neurons, we...
Topics
- Animals
- Behavior, Animal
- Cell Membrane
- Degenerin Sodium Channels
- Dendrites
- Drosophila Proteins
- Drosophila melanogaster
- Epithelial Sodium Channels
- Locomotion
- Mutation