Article
Changes in winter depression phenotype correlate with white blood cell gene expression profiles: a combined metagene and gene ontology approach.
Progress in neuro-psychopharmacology & biological psychiatry - 3 Apr 2015
Bosker Fokko J, Terpstra Peter, Gladkevich Anatoliy V, Janneke Dijck-Brouwer D A, te Meerman Gerard, Nolen Willem A, Schoevers Robert A, Meesters Ybe
Abstract excerpt
In the present study we evaluate the feasibility of gene expression in white blood cells as a peripheral marker for winter depression. Sixteen patients with winter type seasonal affective disorder were included in the study. Blood was taken by venous puncture at three time points; in winter prior and following bright light therapy and in summer. RNA was isolated, converted into cRNA, amplified and hybridized on...
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