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Article

Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage.

Cell reports - 20 Nov 2014

Freije Ana, Molinuevo Rut, Ceballos Laura, Cagigas Marta, Alonso-Lecue Pilar, Rodriguez René, Menendez Pablo, Aberdam Daniel, De Diego Ernesto, Gandarillas Alberto

Abstract excerpt

Tumor suppressor p53 is a major cellular guardian of genome integrity, and its inactivation is the most frequent genetic alteration in cancer, rising up to 80% in squamous cell carcinoma (SCC). By adapting the small hairpin RNA (shRNA) technology, we inactivated endogenous p53 in primary epitheli...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25453755
DOI: 10.1016/j.celrep.2014.10.012

Genes

MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25453755-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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