Article
Retracing the evolutionary path that led to flea-borne transmission of Yersinia pestis.
Cell host & microbe - 14 May 2014
Sun Yi-Cheng, Jarrett Clayton O, Bosio Christopher F, Hinnebusch B Joseph
Abstract excerpt
Yersinia pestis is an arthropod-borne bacterial pathogen that evolved recently from Yersinia pseudotuberculosis, an enteric pathogen transmitted via the fecal-oral route. This radical ecological transition can be attributed to a few discrete genetic changes from a still-extant recent ancestor, thus providing a tractable case study in pathogen evolution and emergence. Here, we determined the genetic and...
Topics
- Animals
- Bacterial Proteins
- Biofilms
- Biological Evolution
- Female
- Humans
- Insect Vectors
- Male
- Mice
- Molecular Sequence Data
- Mutation
- Phylogeny
- Siphonaptera
- Yersinia Infections
- Yersinia pestis
- Yersinia pseudotuberculosis
