Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterisation of multiple regulatory domains spanning the major transcriptional start site of the FUS gene, a candidate gene for motor neurone disease.

Brain research - 21 Jan 2015

Khursheed Kejhal, Wilm Thomas P, Cashman Christine, Quinn John P, Bubb Vivien J, Moss Diana J

Abstract excerpt

Fused-In-Sarcoma (FUS) is a candidate gene for neurological disorders including motor neurone disease and Parkinson׳s disease in addition to various types of cancer. Recently it has been reported that over expression of FUS causes motor neurone disease in mouse models hence mutations leading to changes in gene expression may contribute to the development of neurodegenerative disease. Genome evolutionary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chick Embryo
Share to Dogs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Green Fluorescent Proteins

Share to Motor Neuron Disease

Share to Neuroblastoma

Share to Regulatory Sequences, Nucleic Acid

Share to RNA-Binding Protein FUS

Source

Identifiers

PMID: 25451114
DOI: 10.1016/j.brainres.2014.10.056

Genes

FUS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterisation of multiple regulatory domains spanning the major transcriptional start site of the FUS gene, a candidate gene for motor neurone disease.PMID 25451114Read ↗

Development of a chick embryo model to study important regulatory domains of human genes implicated in Motor Neurone DiseaseSemantic proximity Read ↗

An Evaluation of a SVA Retrotransposon in the FUS Promoter as a Transcriptional Regulator and Its Association to ALSSemantic proximity Read ↗

FUS-mediated alternative splicing in the nervous system: consequences for ALS and FTLDSemantic proximity Read ↗

Characterization of genetic loss-of-function of Fus in zebrafish.Semantic proximity Read ↗

<i>FUS</i> gene is dual-coding with both proteins united in FUS-mediated toxicitySemantic proximity Read ↗

fus/TLS orchestrates splicing of developmental regulators during gastrulation.Semantic proximity Read ↗

FUSDelta14 mutation impairs normal brain development and causes systemic metabolic alterationsSemantic proximity Read ↗

FUS regulates genes coding for RNA-binding proteins in neurons by binding to their highly conserved intronsSemantic proximity Read ↗

Fused in sarcoma (FUS): An oncogene goes awry in neurodegenerationSemantic proximity Read ↗

An ALS-associated mutation in the FUS 3'-UTR disrupts a microRNA-FUS regulatory circuitry.Semantic proximity Read ↗

FUS in familial essential tremor - the search for common causes is still on.Semantic proximity Read ↗

The FUS gene is dual-coding with both proteins contributing to FUS-mediated toxicity.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.