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Article

Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington's disease.

Neurobiology of disease - 1 Feb 2015

Miki Yasuo, Tanji Kunikazu, Mori Fumiaki, Wakabayashi Koichi

Abstract excerpt

The sigma-1 receptor (SIGMAR1) is one of the endoplasmic reticulum (ER) chaperones, which participate in the degradation of misfolded proteins via the ER-related degradation machinery linked to the ubiquitin-proteasome pathway. ER dysfunction in the formation of inclusion bodies in various neurodegenerative diseases has also become evident. Recently, we demonstrated that accumulation of SIGMAR1 was common to...

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Source

Identifiers

PMID: 25449906
DOI: 10.1016/j.nbd.2014.11.005

Genes

SIGMAR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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