Article
PML nuclear bodies and neuronal intranuclear inclusion in polyglutamine diseases.
Neurobiology of disease - 1 Aug 2003
Takahashi Junko, Fujigasaki Hiroto, Iwabuchi Kiyoshi, Bruni Amalia C, Uchihara Toshiki, El Hachimi Khalid H, Stevanin Giovanni, Dürr Alexandra, Lebre Anne Sophie, Trottier Yvon, de Thé Hugues, Tanaka Junichi, Hauw Jean Jacques, Duyckaerts Charles, Brice Alexis
Abstract excerpt
In polyglutamine diseases, accumulation in the nucleus of mutant proteins induces the formation of neuronal intranuclear inclusions (NIIs). The nucleus is compartmentalized into structural and functional domains, which are involved in NII formation. Promyelocytic leukemia protein (PML), a major component of nuclear bodies, and mSin3A, a component of the transcription co-repressor complex, were used to investigate...
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