TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas.

doi:10.1210/jc.2013-3734

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Article

TERT promoter mutations are a major indicator of poor outcome in differentiated thyroid carcinomas.

The Journal of clinical endocrinology and metabolism - 1 May 2014

Melo Miguel, da Rocha Adriana Gaspar, Vinagre João, Batista Rui, Peixoto Joana, Tavares Catarina, Celestino Ricardo, Almeida Ana, Salgado Catarina, Eloy Catarina, Castro Patrícia, Prazeres Hugo, Lima Jorge, Amaro Teresina, Lobo Cláudia, Martins Maria João, Moura Margarida, Cavaco Branca, Leite Valeriano, Cameselle-Teijeiro José Manuel, Carrilho Francisco, Carvalheiro Manuela, Máximo Valdemar, Sobrinho-Simões Manuel, Soares Paula

Abstract excerpt

CONTEXT: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. OBJECTIVES: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognostic significance of such mutations in a large cohort of patients with differentiated thyroid carcinomas (DTCs)....

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Identifiers

PMID: 24476079
DOI: 10.1210/jc.2013-3734
PMCID: PMC4191548

Genes

TERT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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