Article
Type of CFTR mutation determines risk of pancreatitis in patients with cystic fibrosis.
Gastroenterology - 1 Jan 2011
Ooi Chee Y, Dorfman Ruslan, Cipolli Marco, Gonska Tanja, Castellani Carlo, Keenan Katherine, Freedman Steven D, Zielenski Julian, Berthiaume Yves, Corey Mary, Schibli Susanne, Tullis Elizabeth, Durie Peter R
Abstract excerpt
BACKGROUND & AIMS: Different mutations in the cystic fibrosis gene (CFTR) are associated with different functional status of the exocrine pancreas. We investigated whether CFTR genotypes determine the risk of pancreatitis in patients with cystic fibrosis (CF). METHODS: Patients with pancreatic-sufficient CF were identified from 2 CF population-based databases (N = 277; 62 with pancreatitis and 215 without...
Topics
- Adult
- Cohort Studies
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- Exocrine Pancreatic Insufficiency
- Female
- Genotype
- Humans
- Male
- Mutation
- Pancreatitis
- Risk
- Severity of Illness Index