Article
Ethanol administration to cystic fibrosis knockout mice results in increased fatty acid ethyl ester production.
Alcoholism, clinical and experimental research - 1 Nov 2005
Blanco Paola G, Salem Raneem O, Ollero Mario, Zaman Munir M, Cluette-Brown Joanne E, Freedman Steven D, Laposata Michael
Abstract excerpt
BACKGROUND: Fatty acid ethyl esters (FAEE) are nonoxidative ethanol metabolites shown to produce toxic effects in the liver and pancreas in vivo and in vitro. Because alcohol-induced chronic pancreatitis is associated with mutations in the gene responsible for cystic fibrosis (CFTR), we hypothesized that CFTR dysfunction leads to increased levels of these toxic nonoxidative ethanol metabolites following alcohol...
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