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Article

Hi-Plex targeted sequencing is effective using DNA derived from archival dried blood spots.

Analytical biochemistry - 1 Feb 2015

Nguyen-Dumont T, Mahmoodi M, Hammet F, Tran T, Tsimiklis H, Giles G G, Hopper J L, Southey M C, Park D J

Abstract excerpt

Many genetic epidemiology resources have collected dried blood spots (predominantly as Guthrie Cards) as an economical and efficient means of archiving sources of DNA, conferring great value to genetic screening methods that are compatible with this medium. We applied Hi-Plex to screen the breast cancer predisposition gene PALB2 in 93 Guthrie Card-derived DNA specimens previously characterized for PALB2 genetic...

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Source

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Identifiers

PMID: 25447460
DOI: 10.1016/j.ab.2014.10.010
PMCID: PMC4275364

Genes

PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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